Some antidepressants contribute to weight gain more than others, study finds

Antidepressants can cause weight gain as a side effect, which deters some people from taking them. A recent study examined the average weight gain associated with eight commonly prescribed antidepressants. Sertraline, one of the most widely prescribed drugs, was found to cause an average gain of nearly 0.5 pounds (0.2 kilograms) at six months, increasing to 3.2 pounds (1.46 kilograms) at 24 months. The study also identified other antidepressants with an increased risk of weight gain compared to sertraline. The findings can help manage patients’ expectations and guide treatment decisions. Bupropion, however, was associated with a small amount of weight loss.